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Johnson & Johnson's one-shot reduced infection risks by 64 percent in South Africa, where the variant is dominant, compared to 72 percent in the US, where there are only 65 confirmed cases, according to the CDC. Potency was reduced by about five-fold in the lab for Moderna's original shot, and by about two fold for Pfizer's vaccines. The variant doesn't totally nullify the effects of current vaccines - which were designed based on the genetic makeup of earlier circulating forms of the virus - but they do weaken it. In addition to be an estimated 50 percent more infectious, changes in its spike protein - the portion of the virus that allows it to infect human cells - make the variant less 'visible' to antibodies developed based on other forms. We hope to demonstrate that booster doses, if necessary, can be done at lower dose levels, which will allow us to provide many more doses to the global community in late 20 if necessary.'Īlthough the UK's B117 variant is certainly spreading more quickly than other variants, the SOuth African form has much more concerning mutations.
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'Moderna is committed to making as many updates to our vaccine as necessary until the pandemic is under control.
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The immunity someone gains from prior infection with earlier forms of the virus or even the UK's B117 variant is less protective against South Africa's B1351 variant.Īnd the discovery that antibodies to B1351 may offer broader immunity suggests that making vaccines that trigger these immune cells could mean a vaccine for that variant may protect against all of the currently circulating forms.īetter yet: Moderna announced Wednesday that it has shipped enough supplies to the National Institutes of Health (NIH) for trials of its booster shot designed specifically to combat B1351 to begin. The opposite is true of people infected with other variants. Lab tests by Africa Health Research Institute scientists suggests that antibodies triggered by exposure to the country's dominant coronavirus variant can prevent infection by other variants, the scientists said on Wednesday. Scientists have found a potential silver lining to the worrisome South African coronavirus variant: antibodies developed to it may protect against other variants.